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Endocrine Abstracts

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ea0032p11 | Adrenal cortex | ECE2013

Molecular screening for personalized treatment approach in advanced adrenocortical cancer

De Martino Maria Cristina , Al Ghuzlan Abir , Do Cao Christine , Assie Guillaume , Scoazec Jean-Yves , Leboulleux Sophie , Aubert Sebastien , Libe Rossella , Nozieres Cecile , Pattou Francois , Borson-Chazot Francoise , Pivonello Rosario , Mazoyer Clement , Bertherat Jerome , Schlumberger Martin , Lacroix Ludovic , Baudin Eric

Propose: To screen for the presence of putative targets for new treatments in a large cohort of advanced adrenocortical cancer (ACC)Experimental design: In 40 adult stage III-IV ACC primary samples, we used comparative genomic hybridization (CGH) and hotspot gene sequencing (with Ion Torrent) to describe the presence of copy number abnormalities and mutations in more than 40 genes involved in cancer development and putative drug sensitivity (HER2; EGFR; ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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